Bethyl Laboratories
Rabbit anti-WRNIP1 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00282
TargetWRNIP1
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationIHC, IHC-IF
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Product Description
WRNIP1 (Werner helicase interacting protein 1) was identified as a protein that interacts with the N-terminal region of Werner protein (WRN). WRN is a RecQ DNA helicase important to DNA repair and is the causative gene of Werner syndrome (WS), an autosomal recessive disease characterized by premature aging. WRNIP1 has been shown to interact with DNA polymerase delta (pol delta) and play a role in pol delta-mediated DNA synthesis. Additionally, WRNIP1 has been shown to interact with polyubiquitin chains indicating a link between ubiquitination and the DNA repair pathway.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 400 and 450
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetWRNIP1
Antigen Species
Human
Gene ID56897
Gene Symbol
WRNIP1
Gene Name
Werner helicase interacting protein 1
Uniprot IDQ96S55
Protein Name
ATPase WRNIP1
Alternate Names
Product Information
Applications
IHC, IHC-IF
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to WRNIP1 immobilized on solid support.
The epitope recognized by IHC-00282 maps to a region between residue 400 and 450 of human Werner helicase interacting protein 1 using the numbering given in entry NP_064520.2 (GeneID 56897).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Immunohistochemistry-Immunofluoresence (IHC-IF)1:50 - 1:500
Documents
Safety Data SheetPDF · IHC-00282Open
Product DatasheetPDF · IHC-00282 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00282 · Lot 1 (current lot)Open
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