Bethyl Laboratories
Rabbit anti-Cul2 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00692
TargetCul2
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationIHC
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Product Description
Cullin-2 (Cul2) is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. Cul2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13617].
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 150 and 200
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
100 µg/ml
Target Identity
TargetCul2
Antigen Species
Human
Gene ID8453
Gene Symbol
CUL2
Gene Name
cullin 2
Uniprot IDQ13617
Protein Name
Cullin-2
Alternate Names
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to Cul2 immobilized on solid support.
The epitope recognized by IHC-00692 maps to a region between residue 150 and 200 of human cullin 2 using the numbering given in entry NP_003582.2 (GeneID 8453).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00692Open
Product DatasheetPDF · IHC-00692 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00692 · Lot 1 (current lot)Open
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