Rabbit anti-RAN Antibody Affinity Purified
Catalog #
RAN
Human
,Mouse
IHC
,IP
,WB
Rabbit
Polyclonal
Whole IgG
Between 166 and C-terminus
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Human
Dog,
Chicken,
X. laevis,
Bovine,
Rat
Chicken,
X. laevis,
Bovine,
Rat
X. laevis,
Bovine,
Rat
Bovine,
Rat
Rat
Human
2 - 8 °C
1 year from date of receipt
USA
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor [taken from NCBI Entrez Gene (Gene ID: 5901)].
Alternate Names
androgen receptor-associated protein 24; ARA24; Gsp1; GTPase Ran; GTP-binding nuclear protein Ran; guanosine triphosphatase Ran; member RAS oncogene family; OK/SW-cl.81; RanGTPase; ras-like protein TC4; ras-related nuclear protein; TC4
Applications