Rabbit anti-Pericentrin/Kendrin Antibody Affinity Purified
Catalog #
Pericentrin/Kendrin
Human
ICC-IF
,IP
,WB
Rabbit
Polyclonal
Whole IgG
between 175 and 225
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Antibody was affinity purified using an epitope specific to Pericentrin/Kendrin immobilized on solid support.
The epitope recognized by A301-348A maps to a region between residue 175 and 225 of human Pericentrin/Kendrin using the numbering given in entry NP_006022.3 (GeneID 5116).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Antibody was affinity purified using an epitope specific to Pericentrin/Kendrin immobilized on solid support.
The epitope recognized by A301-348A-T maps to a region between residue 175 and 225 of human Pericentrin/Kendrin using the numbering given in entry NP_006022.3 (GeneID 5116).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Pericentrin (PCNT) is a large centrosomal protein that binds calmodulin and mediates assembly of the mitotic spindle apparatus. Depletion of PCNT has been shown to cause apoptosis and activation of the G2/M checkpoint. Recently, mutations in the pericentrin gene have been identified as the cause of primordial dwarfism type II (MOPDII) and Seckel syndrome. Additionally, in cells of Seckel syndrome patients, PCNT has been found to be important to the DNA damage response and ATR-dependent checkpoint signaling.
Alternate Names
KEN; kendrin; MOPD2; PCN; PCNT2; PCNTB; PCTN2; pericentrin; pericentrin-2; pericentrin-380; pericentrin-B; SCKL4
Applications