Rabbit anti-MCSP Antibody Affinity Purified
Catalog #
MCSP
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 575 and 625
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Melanoma chondroitin sulfate proteoglycan (MCSP) is a cell-surface antigen expressed early in melanoma progression. It has been found to be involved in the spreading, invasion, and migration of human melanoma. MCSP influences melanoma behavior via the activation of the Cdc42 GTPase and phosphorylation of p130Cas. MCSP also activates signaling cascades involving FAK and ERK1/ERK2. In addition to its expression in melanoma cells, MCSP is also found in breast carcinomas, gliomas, neuroblastomas, and acute leukemias. MCSP is being considered as a target antigen for cancer immunotherapy.
Alternate Names
chondroitin sulfate proteoglycan 4; chondroitin sulfate proteoglycan 4 (melanoma-associated); chondroitin sulfate proteoglycan NG2; HMW-MAA; MCSP; MCSPG; melanoma chondroitin sulfate proteoglycan; melanoma-associated chondroitin sulfate proteoglycan; MEL-CSPG; MSK16; NG2
Applications