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Primary Antibodies  

Rabbit anti-TDP2 Antibody Affinity Purified

bethyl
Bethyl Laboratories

Catalog #

Validated
Citations (5)
Target:

TDP2

Reactivity:

Human

Applications:

IHC

,

IP

,

WB

Host:

Rabbit

Clonality:

Polyclonal

Format:

Whole IgG

Immunogen:

between 50 and 100

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Antigen Affinity Purified

100 µl (200 µg/ml)

10 µl (200 µg/ml)

Product Details

Specifications
Verified Reactivity

Human

Antigen Species

Human

Concentration
200 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide


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Additional Product Information

TDP2 (5’-Tyr-DNA phosphodiesterase 2) is also known as TTRAP (TRAF and TNF receptor-associated protein). TTRAP is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. TTRAP also hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. TTRAP may also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O95551].

51567

TDP2

tyrosyl-DNA phosphodiesterase 2

O95551

Tyrosyl-DNA phosphodiesterase 2

Alternate Names

5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; AD022; dJ30M3.3; EAP2; EAPII; epididymis secretory sperm binding protein; ETS1-associated protein 2; ETS1-associated protein II; hTDP2; TRAF and TNF receptor-associated protein; TTRAP; tyr-DNA phosphodiesterase 2; tyrosyl-DNA phosphodiesterase 2; tyrosyl-RNA phosphodiesterase; VPg unlinkase

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.