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Primary Antibodies  

Rabbit anti-NIPA Antibody

Bethyl Laboratories®
Bethyl Laboratories®

Catalog #

Validated
Target:

NIPA

Reactivity:

Human

Applications:

IP

Host:

Rabbit

Clonality:

Polyclonal

Format:

Whole IgG

Immunogen:

between 1 and 50

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Antigen Affinity Purified

100 µl (1000 µg/ml)

10 µl (1000 µg/ml)

Product Details

Specifications
Verified Reactivity

Human

Antigen Species

Human

Concentration
1000 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide


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Additional Product Information

Nuclear-interacting partner of ALK (NIPA) is an essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. NIPA may have an antiapoptotic role in NPM-ALK-mediated signaling events [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86WB0].

51530

ZC3HC1

zinc finger C3HC-type containing 1

Q86WB0

Nuclear-interacting partner of ALK

Alternate Names

hematopoietic stem/progenitor cell protein 216; hNIPA; HSPC216; NIPA; nuclear interacting partner of anaplastic lymphoma kinase (ALK); nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; Zinc finger C3HC-type protein 1

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.