/ ANTIBODIES/ANTISERA / Primary Antibodies / Rabbit anti-UBXN1 Antibody
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Primary Antibodies  

Rabbit anti-UBXN1 Antibody Affinity Purified

bethyl
Bethyl Laboratories

Catalog #

Validated
Target:

UBXN1

Reactivity:

Human

Applications:

IP

Host:

Rabbit

Clonality:

Polyclonal

Format:

Whole IgG

Immunogen:

between 262 and 312

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Antigen Affinity Purified

100 µl (1000 µg/ml)

10 µl (1000 µg/ml)

Product Details

Specifications
Verified Reactivity

Human

Presumed Reactivity

Mouse,

Bovine,

Rat

Antigen Species

Human

Concentration
1000 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide


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Additional Product Information

UBX domain-containing protein 1 (UBXN1) is a ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. The interaction between UBXN1 and autoubiquitinated BRCA1, leads to the inhibition the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. UBXN1 is also a component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.3 kDa protein, UBXD10, 2B28, and SAKS1.

51035

UBXN1

UBX domain protein 1

Q04323

UBX domain-containing protein 1

Alternate Names

2B28; SAKS1; SAPK substrate protein 1; UBA/UBX 33.3 kDa protein; UBX domain-containing protein 1; UBXD10

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.