Rabbit anti-Mel-18 Antibody Affinity Purified
Catalog #
Mel-18
Human
WB
Rabbit
Polyclonal
Whole IgG
Between 125 and 175
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Mel18 is a transcriptional repressor and binds specifically to the DNA sequence 5'-GACTNGACT-3'. Mel-18 is a component of a polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Mel-18 has tumor suppressor activity. Mel-18 plays a role in control of cell proliferation and/or neural cell development, and also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P35227].
Alternate Names
DNA-binding protein Mel-18; MEL-18; polycomb group RING finger protein 2; ring finger protein 110; RNF110; zinc finger protein 144; ZNF144
Applications