/ ANTIBODIES/ANTISERA / Primary Antibodies / Rabbit anti-Mre11 Antibody
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Primary Antibodies  

Rabbit anti-Mre11 Antibody Affinity Purified

bethyl
Bethyl Laboratories

Catalog #

Validated
Citations (5)
Target:

Mre11

Reactivity:

Human

Applications:

Flow Cyt

,

IHC

,

IP

,

WB

Host:

Rabbit

Clonality:

Polyclonal

Format:

Whole IgG

Immunogen:

Between 658 and 708

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Antigen Affinity Purified

100 µl (1000 µg/ml)

10 µl (1000 µg/ml)

Product Details

Specifications
Verified Reactivity

Human

Antigen Species

Human

Concentration
1000 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide


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Production Procedures

Antibody was affinity purified using an epitope specific to Mre11 immobilized on solid support.

The epitope recognized by A303-998A maps to a region between residue 658 to 708 of human Meiotic Recombination 11 using the numbering given in entry NP_005582.1 (GeneID 4361).

Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.

Antibody was affinity purified using an epitope specific to Mre11 immobilized on solid support.

The epitope recognized by A303-998A-T maps to a region between residue 658 to 708 of human Meiotic Recombination 11 using the numbering given in entry NP_005582.1 (GeneID 4361).

Additional Product Information

Mre11 is a component of the MRN complex and plays a role in telomere maintenance and double-strand break (DSB) repair. Mre11 associates with rad50 in the MRN complex. Mre11 possesses 3’– 5’ exonuclease activity that is involved in creating DNA termini in DSB suitable for priming DNA synthesis and ligation.

4361

MRE11

MRE11 homolog, double strand break repair nuclease

P49959

Double-strand break repair protein MRE11A

Alternate Names

ATLD; AT-like disease; DNA recombination and repair protein; double-strand break repair protein MRE11; double-strand break repair protein MRE11A; endo/exonuclease Mre11; HNGS1; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; MRE11 double strand break repair nuclease A; MRE11 homolog 1; MRE11 homolog A; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11-like protein A; MRE11A; MRE11B

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.