Rabbit anti-NIR Antibody Affinity Purified
Catalog #
NIR
Human
IHC
,WB
Rabbit
Polyclonal
Whole IgG
Between 699 and 749
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Novel INHAT repressor (NIR) acts as an inhibitor of histone acetyltransferase activity; it prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. NIR acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. It is involved in the regulation of p53/TP53-dependent apoptosis and it associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y3T9].
Nucleolar complex protein 2 homolog
Alternate Names
NET15; NET7; NIR; NOC2L nucleolar associated transcriptional repressor; NOC2-like protein; novel INHAT (inhibitor of histone acetyltransferase) repressor; novel INHAT repressor; nucleolar complex associated 2 homolog; nucleolar complex protein 2 homolog; PPP1R112; protein NOC2 homolog; protein phosphatase 1, regulatory subunit 12
Applications