/ ANTIBODIES/ANTISERA / Primary Antibodies / Rabbit anti-Carbonyl Reductase 1/CBR1 Antibody
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Primary Antibodies  

Rabbit anti-Carbonyl Reductase 1/CBR1 Antibody

Bethyl Laboratories®
Bethyl Laboratories®

Catalog #

Validated
Target:

Carbonyl Reductase 1/CBR1

Reactivity:

Human

Applications:

IP

,

WB

Host:

Rabbit

Clonality:

Polyclonal

Format:

Whole IgG

Immunogen:

Between 227 and 277

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Antigen Affinity Purified

100 µl (1000 µg/ml)

10 µl (1000 µg/ml)

Product Details

Specifications
Verified Reactivity

Human

Antigen Species

Human

Concentration
1000 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide


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Additional Product Information

Carbonyl Reductase 1 / CBR1 is an NADPH-dependent reductase with broad substrate specificity. It catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. It also catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Carbonyl Reductase 1 / CBR1 can convert prostaglandin E2 to prostaglandin F2-alpha [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P16152].

873

CBR1

carbonyl reductase 1

P16152

Carbonyl reductase [NADPH] 1

Alternate Names

15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase NADP(+); carbonyl reductase (NADPH) 1; carbonyl reductase NADPH 1; CBR; epididymis secretory sperm binding protein; hCBR1; NADPH-dependent carbonyl reductase 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; SDR21C1; short chain dehydrogenase/reductase family 21C member 1

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.