Rabbit anti-PAN3 Antibody Affinity Purified
Catalog #
PAN3
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
Between 175 and 225
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
PAB-dependent poly(A)-specific ribonuclease subunit PAN3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q58A45].
PAB-dependent poly(A)-specific ribonuclease subunit PAN3
Alternate Names
PAB1P-dependent poly(A)-nuclease; PAB1P-dependent poly(A)-specific ribonuclease; PAB-dependent poly(A)-specific ribonuclease subunit 3; PAB-dependent poly(A)-specific ribonuclease subunit PAN3; PABP1-dependent poly A-specific ribonuclease subunit PAN3; PABP-dependent poly(A) nuclease 3; PAN deadenylation complex subunit 3; PAN2-PAN3 deadenylation complex subunit PAN3; PAN3 poly(A) specific ribonuclease subunit homolog; poly(A)-nuclease deadenylation complex subunit 3
Applications