Rabbit anti-MTHFD1 Antibody Affinity Purified
Catalog #
MTHFD1
Human
,Mouse
IP
,WB
Rabbit
Polyclonal
Whole IgG
Between 50 and 100
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Human
2 - 8 °C
1 year from date of receipt
Methylenetetrahydrofolate dehydrogenase (MTHFD1) possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain [taken from NCBI Entrez Gene (Gene ID: 4522)].
MTHFD1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
C-1-tetrahydrofolate synthase, cytoplasmic
Alternate Names
5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase; C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase; CIMAH; cytoplasmic C-1-tetrahydrofolate synthase; epididymis secretory sperm binding protein; Formyltetrahydrofolate synthetase; Methylenetetrahydrofolate dehydrogenase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase; MTHFC; MTHFD
Applications