Rabbit anti-PDE12 Antibody
Catalog #
PDE12
Human
WB
Rabbit
Polyclonal
Whole IgG
Between 559 and 609
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse,
Bovine,
Rat
Human
2 - 8 °C
1 year from date of receipt
PDE12 is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3',5'-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6L8Q7].
Alternate Names
2',5'-phosphodiesterase 12; 2'-PDE; 2-PDE; 2'-phosphodiesterase; mitochondrial deadenylase
Applications