Rabbit anti-ZNF207 Antibody Affinity Purified
Catalog #
ZNF207
Human
,Mouse
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 428 and 478
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Human
2 - 8 °C
1 year from date of receipt
ZNF207 is a kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 . According to another report, the stabilization is independent of the proteasome. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43670].
BUB3-interacting and GLEBS motif-containing protein ZNF207
Alternate Names
BUB3-interacting and GLEBS motif-containing protein ZNF207; BuG; ZhBuG; ZZinc finger protein 207
Applications