Mouse anti-HLA-DR Monoclonal Antibody Purified [LN3]
Catalog #
HLA-DR
Human
flow_cyt
,ICC
,IHC
,ihc_if
,WB
COMET™
,PhenoImager™ HT
Mouse
Monoclonal
LN3
Whole IgG
Activated human peripheral blood mononuclear cells
IgG2b
Unconjugated
Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Phosphate Buffered Saline (PBS) with 0.1% BSA and 0.09% Sodium Azide
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Phosphate Buffered Saline (PBS) containing 0.09% Sodium Azide, BSA-Free
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The monoclonal antibody was purified from cell culture supernatant.
Immunogen was activated human peripheral blood mononuclear cells.
In humans, Major Histocompatibility Locus (MHC) class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display ∼70% similarity to each other. Polymorphism is a notable feature of MHC class II genes. HLA-DR, HLA-DP, and HLA-DQ are heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. Variations in the HLA gene expression are crucial to graft survival.
HLA class II histocompatibility antigen, DR alpha chain
Alternate Names
histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR alpha chain; HLA-DRA1; MHC class II antigen DRA
Applications
