Rabbit anti-CD25/IL-2R alpha Recombinant Monoclonal Antibody [BLR158J]
Catalog #
CD25/IL-2R alpha
Human
Flow Cyt
,ICC
,IHC
COMET™
Rabbit
Recombinant Monoclonal
BLR158J
Whole IgG
Between 222 and C-terminus
IgG
Unconjugated
Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide
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Borate Buffered Saline (BBS) pH 8.2 with 0.09% Sodium Azide, BSA-Free
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Recombinant antibody was purified from cell culture supernatant.
Immunogen was a peptide representing a region between residue 222 and the C-terminus (residue 272) of human Interleukin-2 receptor subunit alpha (aka CD25) using the numbering given in entry NP_000408.1 (Gene ID 3559).
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. The IL2 receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. [taken from NCBI Entrez Gene (Gene ID: 3559)].
Alternate Names
