Rabbit anti-TGF-beta 1 Recombinant Monoclonal Antibody [BLR195J]
Catalog #
TGF-beta 1
Human
,Mouse
Flow Cyt
,ICC
,IHC
,WB
Rabbit
Recombinant Monoclonal
BLR195J
Whole IgG
Between 340 and C-terminus
IgG
Unconjugated
Purified
Product Details
Mouse,
Human
Human
2 - 8 °C
1 year from date of receipt
Recombinant antibody was purified from cell culture supernatant.
Immunogen was a peptide representing a region between residue 325 and 375 of human Transforming growth factor beta-1 using the numbering given in entry NP_000651.3 (Gene ID 7040).
The Transforming growth factor beta-1 preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature TGF-beta 1 peptide. TGF-beta 1 bound to LAP is inactive, while the active form consists solely of the mature peptide homodimer. The mature TGF-beta 1 peptide may also form heterodimers with other TGFB family members. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. TGF-beta 1 regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells. [taken from NCBI Entrez Gene (Gene ID: 7040)].
Alternate Names
CED; DPD1; LAP; latency-associated peptide; prepro-transforming growth factor beta-1; TGFB; TGFbeta; TGF-beta-1; transforming growth factor beta-1
Applications
