Rabbit anti-PD-L1 Recombinant Monoclonal Antibody [BLR226K]
Catalog #
PD-L1
Mouse
WB
Rabbit
Recombinant Monoclonal
BLR226K
Whole IgG
residues 19-239 (ECD)
IgG
Unconjugated
Purified
Product Details
Mouse
Human
2 - 8 °C
1 year from date of receipt
PD-L1 is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma [taken from NCBI Entrez Gene (Gene ID: 55193)].
Alternate Names
A530045L16Rik; B7 homolog 1; B7h1; B7-H1; CD antigen CD274; PDCD1 ligand 1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; programmed cell death 1 ligand 1; Programmed death ligand 1
Applications
