Rabbit anti-NBS1 IHC Antibody Affinity Purified
Catalog #
NBS1
Human
IHC
,IHC-IF
Rabbit
Polyclonal
Whole IgG
Between 704 and 754
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Monkey
Human
2 - 8 °C
1 year from date of receipt
Antibody was affinity purified using an epitope specific to NBS1 immobilized on solid support.
The epitope recognized by IHC-00258 maps to a region between residue 704 and 754 of human Nibrin using the numbering given in entry NP_002476.2 (GeneID 4683).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Antibody was affinity purified using an epitope specific to NBS1 immobilized on solid support.
The epitope recognized by IHC-00258-T maps to a region between residue 704 and 754 of human Nibrin using the numbering given in entry NP_002476.2 (GeneID 4683).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Mutations in NBS1 (Nijmegen Breakage Syndrome 1), also known as nibrin, are associated with the autosomal recessive syndrome, Nijmegen breakage syndrome, characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. At the cellular level, NBS1 is part of the MRE11/RAD50 double-strand break repair complex that is critical to the DNA damage response, DNA recombination, telomere integrity, and cell cycle checkpoint control.
Alternate Names
ATV; AT-V1; AT-V2; cell cycle regulatory protein p95; NBS; NBS1; nibrin; Nijmegen breakage syndrome 1 (nibrin); Nijmegen breakage syndrome protein 1; P95; p95 protein of the MRE11/RAD50 complex
Applications