Rabbit anti-AKAP8L/HA95 IHC Antibody
Catalog #
AKAP8L/HA95
Human
IHC
,IHC-IF
Rabbit
Polyclonal
Whole IgG
Between 596 and 646
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington’s disease.
Alternate Names
A kinase (PRKA) anchor protein 8-like; AKAP8-like protein; A-kinase anchor protein 8-like; HA95; HAP95; Helicase A-binding protein 95; helicase A-binding protein 95 kDa; homologous to AKAP95 protein; NAKAP; NAKAP95; neighbor of AKAP95; neighbor of A-kinase anchoring protein 95; Neighbor of A-kinase-anchoring protein 95; testis tissue sperm-binding protein Li 90mP
Applications
