Rabbit anti-FKBP4/FKBP52 IHC Antibody Affinity Purified
Catalog #
FKBP4/FKBP52
Human
IHC
,IHC-IF
Rabbit
Polyclonal
Whole IgG
Between 1 and 50
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Guinea Pig,
Mouse,
Pig,
Rabbit,
Bovine,
Monkey,
Rat
Human
2 - 8 °C
1 year from date of receipt
Antibody was affinity purified using an epitope specific to FKBP4/FKBP52 immobilized on solid support.
The epitope recognized by IHC-00290 maps to a region between residue 1 and 50 of human FK506 binding protein 4 using the numbering given in entry NP_002005.1 (GeneID 2288).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Antibody was affinity purified using an epitope specific to FKBP4/FKBP52 immobilized on solid support.
The epitope recognized by IHC-00290-T maps to a region between residue 1 and 50 of human FK506 binding protein 4 using the numbering given in entry NP_002005.1 (GeneID 2288).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
FKBP4/FKBP52 is an immunophilin and target of FK506, a macrolide immunosuppressive drug derived from Streptomyces tsukubaensis. Like other FK506 binding proteins, FKBP52 exhibits peptidyl-prolyl cis-trans isomerase activity, but does not appear to mediate the immunosuppressive activities of FK506. The most studied role of FKBP4/FKBP52 surrounds its involvement in the regulation of steroid receptor signaling. In association with the molecular chaperone Hsp90, FKBP4/FKBP52 is able to influence steroid-hormone binding affinity and transcriptional activity.
Alternate Names
51 kDa FK506-binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4, 59kDa; FK506-binding protein 4; FKBP-4; FKBP51; FKBP52; FKBP-52; FKBP59; HBI; HSP binding immunophilin; Hsp56; HSP-binding immunophilin; Immunophilin FKBP52; p52; p59; peptidylprolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase FKBP4; PPIase; PPIase FKBP4; rotamase; T-cell FK506-binding protein, 59kD
Applications
