Rabbit anti-KPNA4 IHC Antibody Affinity Purified
Catalog #
KPNA4
Human
,Mouse
IHC
,IHC-IF
Rabbit
Polyclonal
Whole IgG
Between 471 and 521
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Guinea Pig,
Horse,
Dog,
Rabbit,
Bovine,
Monkey
Human
2 - 8 °C
1 year from date of receipt
Antibody was affinity purified using an epitope specific to KPNA4 immobilized on solid support.
The epitope recognized by IHC-00321 maps to a region between residue 471 and 521 of human karyopherin alpha 4 using the numbering given in entry NP_002259.1 (GeneID 3840).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Antibody was affinity purified using an epitope specific to KPNA4 immobilized on solid support.
The epitope recognized by IHC-00321-T maps to a region between residue 471 and 521 of human karyopherin alpha 4 using the numbering given in entry NP_002259.1 (GeneID 3840).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
KPNA4 (karyopherin alpha 4), also known as importin alpha 3, is a member of the importin alpha family of proteins which includes KPNA1 (importin alpha 5), KPNA2 (importin alpha 1), KPNA3 (importin alpha 4), KPNA4 (importin alpha 3), KPNA5 (importin alpha 6), and KPNA6 (importin alpha 7). The importin alpha family of proteins plays a role in the import of proteins from the cytoplasm to the nucleus. The import of proteins from the cytoplasm to the nucleus involves docking the protein to receptors associated with the nuclear pore complex (NPC) followed by translocation through the nuclear pore. Importin alpha proteins bind the nuclear localization signal (NLS) of cargo proteins and function as adaptor proteins for the nuclear pore receptor KPNB1 (importin beta 1). KPNB1 is responsible for docking the importin-cargo complex to the cytoplasmic side of the NPC for its translocation through the NPC. KPNA3 (Importin alpha 4) and KPNA4 (importin alpha 3) have been reported to mediate the nuclear import of TNF-alpha induced nuclear import of NF-kappaB p50/p65 heterodimers. RNA interference experiments have shown that KPNA4 is important for HeLa cell proliferation and the nuclear import of the Ran guanine nucleotide exchange factor, RCC1.
Alternate Names
importin alpha Q1; importin subunit alpha-3; importin subunit alpha-4; IPOA3; karyopherin alpha 4 (importin alpha 3); Karyopherin subunit alpha-4; QIP1; SRP3
Applications
