Rabbit anti-Flightless-1 IHC Antibody Affinity Purified
Catalog #
Flightless-1
Human
IHC
,IHC-IF
Rabbit
Polyclonal
Whole IgG
Between 425 and 475
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Antibody was affinity purified using an epitope specific to Flightless-1 immobilized on solid support.
The epitope recognized by IHC-00340 maps to a region between residue 425 and 475 of human Flightless-1 using the numbering given in entry NP_002009.1 (GeneID 2314).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Antibody was affinity purified using an epitope specific to Flightless-1 immobilized on solid support.
The epitope recognized by IHC-00340-T maps to a region between residue 425 and 475 of human Flightless-1 using the numbering given in entry NP_002009.1 (GeneID 2314).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Flightless-1 is the human homolog of the drosophila flightless (fli1), a gene required for proper development of flight muscles and essential to embryonic development. It is a member of the gelsolin family of actin-binding proteins, and is highly conserved among vertebrates and invertebrates. The actin-remodeling activity of flightless-1 may have multiple roles in the cell. Studies in transgenic mice indicate a role in wound healing that may involve the regulation of cell migration and proliferation. Flightless-1 has also been found to be associated with complexes involved in transcriptional regulation. It associates with CARM1, a protein arginine methyltransferase, and may function as a nuclear receptor coactivator via this interaction. It has also been shown to associate with the BAF53a subunit of the SWI/SNF-like chromatin remodeling complexes.
Alternate Names
FLI; Fli1; flightless I actin binding protein; flightless I homolog; FLIL; protein flightless-1 homolog
Applications
