Rabbit anti-CSN5 IHC Antibody Affinity Purified
Catalog #
CSN5
Human
,Mouse
IHC
Rabbit
Polyclonal
Whole IgG
Between 175 and 225
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Guinea Pig,
Horse,
Zebra Finch,
Turkey,
Dog,
Chicken,
Pig,
Rabbit,
X. laevis,
X. tropicalis,
Zebrafish,
Bovine,
Monkey,
Rat
Human
2 - 8 °C
1 year from date of receipt
CSN5 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. CSN also possesses kinase activity. CSN5 has been identified as the subunit that functions to remove Nedd8, an ubiquitin-like modifier, from cullin-based E3-ubiquitin ligases. CSN5 also functions as a coactivator of nuclear receptors. COP9 signalsome complex subunit 5, signalsome subunit 5, SGN5, jun activation domain-protein 1, COPS5, JAB1, MOV-34, MGC3149.
Alternate Names
38 kDa Mov34 homolog; COP9 constitutive photomorphogenic homolog subunit 5; COP9 signalosome complex subunit 5; CSN5; JAB1; jun activation domain-binding protein 1; MOV-34; SGN5; signalosome subunit 5; testis secretory sperm-binding protein Li 231m
Applications