Bethyl Laboratories® Rabbit anti-CSTF2T/TauCSTF64 IHC Antibody, Affinity Purified - 100 µl (50+ slides)
Catalog #
CSTF2T/TauCSTF64
Human
IHC
Rabbit
Polyclonal
Whole IgG
Between 566 and C-terminus
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Guinea Pig,
Mouse,
Horse,
Dog,
Pig,
Rabbit,
Rat
Human
2 - 8 °C
1 year from date of receipt
CSTF2T, also known as tauCSTF-64, is a paralog of CstF-64, a component of the cleavage stimulation factor (CstF) that processes 3’-end formation and polyadenylation of mRNAs. The human CSTF2T/TauCSTF64 gene is located at 10q22-23, a site associated with neurological problems and male infertility. CSTF2T is expressed in all tissues and throughout meiosis in male germ cells. CstF-64 is also expressed ubiquitously; however because it is located on the X chromosome, its expression is temporarily silenced in germ cells by meiotic sex chromosome inactivation. During this inactivation, it is hypothesized that CSTF2T/TauCSTF64 can compensate for the loss of CstfF-64 expression. Recently, targeted disruption of CSTF2T/TauCSTF64 in mice has been shown to cause aberrant spermatogenesis and infertility providing more evidence for its importance in spermatogenesis.
Cleavage stimulation factor subunit 2 tau variant
Alternate Names
CF-1 64 kDa subunit tau; CF-1 64 kDa subunit tau variant; cleavage stimulation factor 64 kDa subunit tau; Cleavage stimulation factor 64 kDa subunit tau variant; cleavage stimulation factor subunit 2 tau variant; cleavage stimulation factor subunit 2, tau; cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau; cleavage stimulation factor, 3' pre-RNA, subunit 2, tau; CSTF 64 kDa subunit tau; CSTF 64 kDa subunit tau variant; CstF-64T; tauCstF-64
Applications
