/ ANTIBODIES/ANTISERA / MAPK Pathway Antibodies / Rabbit anti-PPM1B Antibody
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MAPK Pathway Antibodies  

Rabbit anti-PPM1B Antibody

Bethyl Laboratories®
Bethyl Laboratories®

Catalog #

Validated
Citations (5)
Target:

PPM1B

Reactivity:

Human

Applications:

IP

,

WB

Host:

Rabbit

Clonality:

Polyclonal

Format:

Whole IgG

Immunogen:

between 450 and C-term

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Antigen Affinity Purified

100 µl (200 µg/ml)

10 µl (200 µg/ml)

Product Details

Specifications
Verified Reactivity

Human

Antigen Species

Human

Concentration
200 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide


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Additional Product Information

Members of the protein phosphatase 2C (PP2C) family of isoenzymes are serine/threonine protein phosphatases that act as monomers, are magnesium or manganese dependent, and are structurally distinct from PP1, PP2A, and PP2B protein phosphatases. There are 14 mammalian PP2C genes that encode for members of the PP2C family of isoenzymes. Members of this family include PP2C alpha (PPM1A), PP2C beta (PPM1B), PP2C gamma (PPM1G), and PP2C delta (PPM1D). PPM1B represents the protein phosphatase 2C (PP2C) beta isoform 1. Six splice variants of the PPM1B have been identified PPM1B activation by lipophilic compounds has been demonstrated to be associated with the induction of apoptosis PPM1B activity has been shown to be involved in cell cycle control and the dephosphorylation of cyclin dependent kinases cdk2 and cdk6.

5495

PPM1B

protein phosphatase, Mg2+/Mn2+ dependent 1B

O75688

Protein phosphatase 1B

Alternate Names

PP2CB; PP2CBETA; PP2C-beta; PP2C-beta-X; PPC2BETAX; protein phosphatase 1B; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; Protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; Ser/Thr protein phosphatase type 2C beta 2 isoform

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.