Signal Transduction
Browse through our range of validated signal transduction antibodies to find suitable products for your research application. Filter by target, application, host and more to find the right product for you. View documentation, citations and available distributors for all antibodies listed.
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Between Yes and No: B7-H4 and T-cell ActivationCraig Vollert, Ph.D. candidateArticleImmunotherapy has become an increasingly important therapeutic option for treating both autoimmune diseases and various cancers. Based on the two-signal hypothesis for T-cell activation, the goal is to either decrease the deleterious effect of an overactive immune system as is the case with autoimmune diseases or the opposite, increase the immune response to enable targeted killing of cancer cells.
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CD247/CD3Z: The Gatekeeper of T-cell ActivationCraig Vollert, Ph.D. candidateArticleThe TCR-CD3 complex plays an essential role in the adaptive immune response. Present on the cell surface, the T-cell receptor (TCR) initiates T-cell activation by recognizing antigens bound to the major histocompatibility complex (MHC) molecule.1 However, due to the TCR’s extremely sort cytoplasmic tail it is dependent on the CD3 complex for signaling, effectively making the CD3 complex the gatekeeper for T-cell activation.2 While the CD3 complex consists of multiple components, CD247/CD3Z is arguably the most important due to its role in signal transduction and its potential use as a biomarker for evaluating the status of immune system.3
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In-Depth with CD137Aliyah Weinstein, Ph.D.ArticleCD137, also known as 4-1BB, ILA, and TNFRSF9, is a member of the TNF family that was originally identified through genetic screens as being expressed on activated T cells.1 CD137 is expressed on transitional CD45RA+ CD45RO+ T cells.2 and activated CD8+ and CD4+ T cells3,4 It can be used as a marker for CD8+ T cells that are antigen-experienced. CD137 can also be expressed on dendritic cells, where ligation promotes cell survival and activation, and increases the duration of contact between dendritic cells and T cells.5,6
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It's Getting Hot In Here: CD163 and InflammationJessica J. DeWitt, Ph.D.ArticleIt finally happened! The moment you've been waiting for: your manuscript was accepted for publication! You decide to take a vacation to celebrate. You deserve the break, and you haven’t taken a vacation in years. You think somewhere tropical might be nice. You pack quickly but forget one crucial item: mosquito repellant. What happens if you get malaria? Malaria is a blood disease caused by microorganisms and transmitted by mosquitos in certain parts of the world. In advanced malaria, blood cells are lysed in the human host, releasing hemoglobin from the cells1.
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KAP-1: Many Names, Even More FunctionsJane Naberhuis, Ph.D.ArticleKrüppel-associated box (KRAB) domain-associated protein 1 (KAP-1), also known as tripartite motif-containing 28 (TRIM28), transcriptional intermediary factor 1 beta (TIF1β), and KRAB-A-interacting protein 1 (KRIP1) was first identified over 20 years ago.1 Since then, the function of KAP-1 in numerous cellular processes has been described, including in neurology, stress behavior, immunology, developmental biology, cellular proliferation and maturation, virology, genome integrity, cancer biology, and DNA damage response.1,2
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